PDE5 inhibited
Tadalafil blocks PDE5, the enzyme that breaks down cGMP, the chemical signal that keeps blood vessels relaxed.
Daily tadalafil (generic for Cialis®)
One low dose a day. Always ready.
Tadalafil relaxes blood vessels. Taken daily at a low dose, it holds a steady level in your body, so there is no window to plan around.
- Always ready. A steady daily level means no timing a dose and no planning ahead.
- FDA-approved. For erectile dysfunction, and at 5 mg for the signs and symptoms of an enlarged prostate.
- One small tablet. With or without food. Prescribed only when a licensed provider decides it is appropriate.
Provider-reviewed
Every prescription reviewed by a U.S. licensed physician for your state.
Licensed U.S. pharmacy
Dispensed by a licensed, accredited U.S. pharmacy.
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Arrives in plain packaging with tracking.
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Blocks one enzyme. Opens blood vessels.
Tadalafil acts on a single enzyme in your vascular system. That one action is what supports an erection, and it is the same action researchers are studying for vascular health.
cGMP preserved
With PDE5 blocked, cGMP stays active longer. Blood vessels stay relaxed and blood moves more freely.
A 17.5-hour half-life
Tadalafil clears slowly. That is why one low dose a day holds a steady level instead of peaking and wearing off.
Steady state in five days
Taken once daily, tadalafil reaches a stable concentration in about five days. After that it is simply there.
Pharmacokinetics per the CIALIS prescribing information. Tadalafil is FDA-approved for erectile dysfunction and, at 5 mg, for the signs and symptoms of benign prostatic hyperplasia.
Blood vessels tighten as you age. Tadalafil helps keep them open.
Men who took daily tadalafil experienced:
0%Lower Risk
All cause mortality
0%Lower Risk
Cardiovascular death
0%Lower Risk
Major cardiac events
No Tadalafil
Tadalafil
1Kloner et al., “The Association of Tadalafil Exposure With Lower Rates of Major Adverse Cardiovascular Events and Mortality,” Clinical Cardiology (2024). Groups matched for blood-pressure, diabetes and cholesterol medications. Risk shown against men not taking tadalafil, indexed to 100. Observational data show association, not cause and effect. Tadalafil is FDA-approved for ED and BPH; it is not approved to prevent cardiovascular disease. Individual results vary.
Why daily?
Steady by design
A low dose every day keeps a constant level in your bloodstream rather than a peak that fades.
Nothing to plan
No window to hit, no meal to time around, no deciding in advance whether tonight is the night.
A lower dose
2.5 mg or 5 mg daily, against 10 mg to 20 mg taken as needed. Side effects track with dose.
Common questions
Tadalafil is the FDA-approved active ingredient in Cialis®. At a low daily dose (2.5–5 mg), it's approved to treat erectile dysfunction, and also the urinary symptoms of benign prostatic hyperplasia (BPH).
One tablet, once a day, at roughly the same time, with or without food. Your provider determines the right dose based on your health history.
Daily dosing builds to a steady level over several days rather than working from a single dose, so once you're at steady state there's no timing window to plan around.
The most common are headache, flushing, nasal congestion, indigestion, and back or muscle aches. These are generally mild and often settle as your body adjusts. See the full Important Safety Information.
Don't take tadalafil with nitrate medications (such as nitroglycerin), the combination can cause a dangerous drop in blood pressure. It may also be unsuitable with significant heart disease, uncontrolled blood pressure, or severe liver or kidney conditions. A licensed provider reviews your full history before prescribing.
We offer telehealth consultations and prescription fulfillment in 49 U.S. states, every state except South Carolina.
See if daily tadalafil is right for you
A short online visit. A licensed provider reviews your history and decides whether treatment is appropriate. You are only charged if you are prescribed.